Trypanosome doublet microtubule structures reveal flagellum assembly and motility mechanisms

Abstract excerpt

The flagellum of Trypanosoma brucei drives the parasite’s characteristic screw-like motion and is essential for its replication, transmission, and pathogenesis. However, the molecular details of this process remain unclear. Here, we present high-resolution (up to 2.8 angstrom) cryo–electron microscopy structures of T. brucei flagellar doublet microtubules (DMTs). Integrated modeling identified 154 different...

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