Article
Three outer arm dynein heavy chains of Chlamydomonas reinhardtii operate in a coordinated fashion both in vitro and in vivo.
Cytoskeleton (Hoboken, N.J.) - 1 Jul 2010
Takazaki Hiroko, Liu Zhongmei, Jin Mingyue, Kamiya Ritsu, Yasunaga Takuo
Abstract excerpt
Outer arm dynein (OAD) in cilia and flagella contains two to three nonidentical heavy chains (HCs) that possess motor activity. In Chlamydomonas, flagellar OAD contains three HCs, alpha-, beta-, and gamma-HCs, each appearing to have a distinct role. To determine the precise molecular mechanism of their function, cross-sectional electron micrographs of wild-type and single HC-disruption mutants were compared and...
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