Article
Local phylogeny mapping of quantitative traits: higher accuracy and better ranking than single-marker association in genomewide scans.
Genetics - 1 Feb 2009
Besenbacher Søren, Mailund Thomas, Schierup Mikkel H
Abstract excerpt
We present a new method, termed QBlossoc, for linkage disequilibrium (LD) mapping of genetic variants underlying a quantitative trait. The method uses principles similar to a previously published method, Blossoc, for LD mapping of case/control studies. The method builds local genealogies along the genome and looks for a significant clustering of quantitative trait values in these trees. We analyze its efficiency...
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