Clade Distillation for Genome-wide Association Studies

Abstract excerpt

Testing inferred haplotype genealogies for association with phenotypes has been a longstanding goal in human genetics with several underlying challenges. A key advantage of these methods is the potential to detect association signals caused by allelic heterogeneity — when multiple causal variants modulate a phenotype — in both coding and noncoding regions. Recent scalable methods for inferring locus-specific genea...

Topics

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• Algorithms
• Genome-Wide Association Study
• Haplotypes
• Markov Chains
• Models, Genetic
• Phenotype
• Polymorphism, Single Nucleotide
• Quantitative Trait Loci

Identifiers and source

Literature Corpus work

849431fc-9f70-5fc1-b23b-7f27540dffb0

DOI

10.1101/2024.09.30.615852