Article
Tree-based QTL mapping with expected local genetic relatedness matrices.
American journal of human genetics - 7 Dec 2023
Link Vivian, Schraiber Joshua G, Fan Caoqi, Dinh Bryan, Mancuso Nicholas, Chiang Charleston W K, Edge Michael D
Abstract excerpt
Understanding the genetic basis of complex phenotypes is a central pursuit of genetics. Genome-wide association studies (GWASs) are a powerful way to find genetic loci associated with phenotypes. GWASs are widely and successfully used, but they face challenges related to the fact that variants are tested for association with a phenotype independently, whereas in reality variants at different sites are correlated...
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