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Article

Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort.

The Journal of clinical endocrinology and metabolism - 1 Apr 2005

Haiman Christopher A, Riley Stephanie E, Freedman Matthew L, Setiawan Veronica W, Conti David V, Le Marchand Loïc

Abstract excerpt

SHBG transports sex steroid hormones in the blood, and levels in humans are thought to partially be genetically determined. Recently, studies have found a pentanucleotide (TAAAA)n repeat polymorphism in the promoter of the SHBG gene and a missense polymorphism in exon 6 (Asp327Asn) to predict circulating SHBG levels. Based on the potential role of common genetic variation in SHBG to serve as a marker of SHBG...

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Source

Identifiers

PMID: 15634719
DOI: 10.1210/jc.2004-1417

Genes

SHBG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Common genetic variation in the sex steroid hormone-binding globulin (SHBG) gene and circulating shbg levels among postmenopausal women: the Multiethnic Cohort.PMID 15634719Read ↗

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Associations of serum sex hormone binding globulin (SHBG) levels with SHBG gene polymorphisms in the CARDIA Male Hormone Study.Semantic proximity Read ↗

Association of the (TAAAA)n repeat polymorphism in the sex hormone-binding globulin (SHBG) gene with polycystic ovary syndrome and relation to SHBG serum levels.Semantic proximity Read ↗

Influence of SHBG gene pentanucleotide TAAAA repeat and D327N polymorphism on serum sex hormone-binding globulin concentration in hirsute women.Semantic proximity Read ↗

Genetic variants of sex hormone-binding globulin and their biological consequences.Semantic proximity Read ↗

Association between SHBG Asp327Asn (rs6259) polymorphism and breast cancer risk: a meta-analysis of 10,454 cases and 13,111 controls.Semantic proximity Read ↗

Polymorphisms of the SHBG gene contribute to the interindividual variation of sex steroid hormone blood levels in young, middle-aged and elderly men.Semantic proximity Read ↗

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SHBG gene promoter polymorphisms in men are associated with serum sex hormone-binding globulin, androgen and androgen metabolite levels, and hip bone mineral density.Semantic proximity Read ↗

Polymorphisms in the SHBG gene influence serum SHBG levels in women with polycystic ovary syndrome.Semantic proximity Read ↗

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