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Article

Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.

Developmental biology - 15 Jan 2011

Miyamoto Rieko, Jijiwa Mayumi, Asai Masato, Kawai Kumi, Ishida-Takagishi Maki, Mii Shinji, Asai Naoya, Enomoto Atsushi, Murakumo Yoshiki, Yoshimura Akihiko, Takahashi Masahide

Abstract excerpt

The glial cell line-derived neurotrophic factor (GDNF)/RET tyrosine kinase signaling pathway plays crucial roles in the development of the enteric nervous system (ENS) and the kidney. Tyrosine 1062 (Y1062) in RET is an autophosphorylation residue that is responsible for the activation of the PI3K...

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Source

Identifiers

PMID: 21070764
DOI: 10.1016/j.ydbio.2010.11.002

Genes

RET
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21070764-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice.PMID 21070764Read ↗

Loss of Sprouty1 rescues renal agenesis caused by Ret mutation.Semantic proximity Read ↗

A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia.Semantic proximity Read ↗

Kidney Development in the Absence of Gdnf and Spry1 Requires Fgf10Semantic proximity Read ↗

Sprouty1 is a critical regulator of GDNF/RET-mediated kidney induction.Semantic proximity Read ↗

Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling.Semantic proximity Read ↗

Gdnf haploinsufficiency causes Hirschsprung-like intestinal obstruction and early-onset lethality in mice.Semantic proximity Read ↗

Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.Semantic proximity Read ↗

Deciphering adaptor specificity in GFL-dependent RET-mediated proliferation and neurite outgrowth.Semantic proximity Read ↗

Sprouty proteins regulate ureteric branching by coordinating reciprocal epithelial Wnt11, mesenchymal Gdnf and stromal Fgf7 signalling during kidney development.Semantic proximity Read ↗

GDNF is required for kidney development and enteric innervation.Semantic proximity Read ↗

Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform.Semantic proximity Read ↗

GFR alpha1-deficient mice have deficits in the enteric nervous system and kidneys.Semantic proximity Read ↗

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