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Article

Concordant analysis of KRAS, BRAF, PIK3CA mutations, and PTEN expression between primary colorectal cancer and matched metastases.

Scientific reports - 2 Feb 2015

Mao Chen, Wu Xin-Yin, Yang Zu-Yao, Threapleton Diane Erin, Yuan Jin-Qiu, Yu Yuan-Yuan, Tang Jin-Ling

Abstract excerpt

Current data on the concordance of KRAS, BRAF, PIK3CA mutation status or PTEN expression status between primary tumors and metastases in colorectal cancer (CRC) are conflicting. We conducted a systematic review and meta-analysis to examine concordance and discordance of the status of these four biomarkers between primary tumors and corresponding metastases in CRC patients. The biomarker status in primary tumors...

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Source

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Identifiers

PMID: 25639985
DOI: 10.1038/srep08065
PMCID: PMC4648436

Genes

KRAS
BRAF
PTEN
EGFR

Provenance

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