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Article

Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.

DNA repair - 1 Mar 2009

Kaniak Aneta, Dzierzbicki Piotr, Rogowska Agata T, Malc Ewa, Fikus Marta, Ciesla Zygmunt

Abstract excerpt

The proximity of the mitochondrial genome to the respiratory chain, a major source of ROS (radical oxygen species), makes mtDNA more vulnerable to oxidative damage than nuclear DNA. Mitochondrial BER (base excision repair) is generally considered to be the main pathway involved in the prevention of oxidative lesion-induced mutations in mtDNA. However, we previously demonstrated that the increased frequency of...

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Source

Identifiers

PMID: 19056520
DOI: 10.1016/j.dnarep.2008.11.004

Genes

OGG1
SOD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.PMID 19056520Read ↗

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Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome.Semantic proximity Read ↗

The generation of oxidative stress-induced rearrangements in Saccharomyces cerevisiae mtDNA is dependent on the Nuc1 (EndoG/ExoG) nuclease and is enhanced by inactivation of the MRX complex.Semantic proximity Read ↗

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