Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome.

DNA repair - 3 Feb 2006

Vongsamphanh Ratsavarinh, Wagner J Richard, Ramotar Dindial

Abstract excerpt

Reactive oxygen species can attack the mitochondrial genome to produce a vast array of oxidative DNA lesions including 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo). We assess the role of the Saccharomyces cerevisiae 8-oxo-dGuo DNA glycosylase, Ogg1, in the maintenance of a poly(GT) tract reporter system present in the mitochondrial genome. Deletion in the poly(GT) tract causes the reporter system to produce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arginine
Share to Chromatography, High Pressure Liquid
Share to DNA Glycosylases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Fungal Proteins

Share to Genome, Fungal

Share to Green Fluorescent Proteins

Share to Peptides

Share to Substrate Specificity

Source

Identifiers

PMID: 16293446
DOI: 10.1016/j.dnarep.2005.10.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Saccharomyces cerevisiae Ogg1 prevents poly(GT) tract instability in the mitochondrial genome.PMID 16293446Read ↗

Inactivation of Saccharomyces cerevisiae OGG1 DNA repair gene leads to an increased frequency of mitochondrial mutants.Semantic proximity Read ↗

Ntg1p, the base excision repair protein, generates mutagenic intermediates in yeast mitochondrial DNA.Semantic proximity Read ↗

The 3'->5' exonuclease of Apn1 provides an alternative pathway to repair 7,8-dihydro-8-oxodeoxyguanosine in Saccharomyces cerevisiae.Semantic proximity Read ↗

Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway.Semantic proximity Read ↗

Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.Semantic proximity Read ↗

Inactivation of OGG1 increases the incidence of G . C-->T . A transversions in Saccharomyces cerevisiae: evidence for endogenous oxidative damage to DNA in eukaryotic cells.Semantic proximity Read ↗

Drosophila Ogg1 is required to suppress 8-oxo-guanine accumulation following oxidative stress.Semantic proximity Read ↗

Spontaneous mutation, oxidative DNA damage, and the roles of base and nucleotide excision repair in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

Biological significance of the defense mechanisms against oxidative damage in nucleic acids caused by reactive oxygen species: from mitochondria to nuclei.Semantic proximity Read ↗

Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

The defense mechanisms in mammalian cells against oxidative damage in nucleic acids and their involvement in the suppression of mutagenesis and cell death.Semantic proximity Read ↗

Rat 7,8-dihydro-8-oxoguanine DNA glycosylase: substrate specificity, kinetics and cleavagemechanism at an apurinic site.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.