Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antimutator alleles of yeast DNA polymerase gamma modulate the balance between DNA synthesis and excision.

PloS one - 1 Jan 2011

Foury Françoise, Szczepanowska Karolina

Abstract excerpt

Mutations in mitochondrial DNA (mtDNA) are an important cause of disease and perhaps aging in human. DNA polymerase gamma (pol γ), the unique replicase inside mitochondria, plays a key role in the fidelity of mtDNA replication through selection of the correct nucleotide and 3'-5' exonuclease proofreading. For the first time, we have isolated and characterized antimutator alleles in the yeast pol γ (Mip1). These...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to DNA Polymerase gamma
Share to DNA Polymerase I

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Replication

Share to Electrophoretic Mobility Shift Assay

Share to Exonucleases

Share to Mutation Rate

Share to Saccharomyces cerevisiae Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 22114710
DOI: 10.1371/journal.pone.0027847
PMCID: PMC3218072

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antimutator alleles of yeast DNA polymerase gamma modulate the balance between DNA synthesis and excision.PMID 22114710Read ↗

The Saccharomyces cerevisiae mitochondrial DNA polymerase and its contribution to the knowledge about human POLG-related disorders.Semantic proximity Read ↗

Mitochondrial DNA defects in Saccharomyces cerevisiae caused by functional interactions between DNA polymerase gamma mutations associated with disease in human.Semantic proximity Read ↗

Analysis of yeast pms1, msh2, and mlh1 mutators points to differences in mismatch correction efficiencies between prokaryotic and eukaryotic cells.Semantic proximity Read ↗

A non-radioactive DNA synthesis assay demonstrates that elements of the Sigma 1278b Mip1 mitochondrial DNA polymerase domain and C-terminal extension facilitate robust enzyme activity.Semantic proximity Read ↗

dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants.Semantic proximity Read ↗

The Y951N patient mutation inactivates the intramolecular switch in human mitochondrial DNA POLγSemantic proximity Read ↗

Mutator suppression and escape from replication error-induced extinction in yeast.Semantic proximity Read ↗

The fidelity of human DNA polymerase gamma with and without exonucleolytic proofreading and the p55 accessory subunit.Semantic proximity Read ↗

Antimutator variants of DNA polymerases.Semantic proximity Read ↗

Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway.Semantic proximity Read ↗

Evidence that DNA polymerase δ proofreads errors made by DNA polymerase α across the Saccharomyces cerevisiae nuclear genome.Semantic proximity Read ↗

Instability throughout the Saccharomyces cerevisiae genome resulting from Pms1 endonuclease deficiency.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.