Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence that msh1p plays multiple roles in mitochondrial base excision repair.

Genetics - 1 Jul 2009

Pogorzala Leah, Mookerjee Shona, Sia Elaine A

Abstract excerpt

Mitochondrial DNA is thought to be especially prone to oxidative damage by reactive oxygen species generated through electron transport during cellular respiration. This damage is mitigated primarily by the base excision repair (BER) pathway, one of the few DNA repair pathways with confirmed activity on mitochondrial DNA. Through genetic epistasis analysis of the yeast Saccharomyces cerevisiae, we examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Fungal
Share to Adenosine Triphosphatases
Share to Adenosine Triphosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-(Apurinic or Apyrimidinic Site) Lyase

Share to DNA Repair Enzymes

Share to Endodeoxyribonucleases

Share to Epistasis, Genetic

Share to Mitochondrial Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 19398768
DOI: 10.1534/genetics.109.103796
PMCID: PMC2710152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence that msh1p plays multiple roles in mitochondrial base excision repair.PMID 19398768Read ↗

Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.Semantic proximity Read ↗

A dominant mitochondrial mutator phenotype of Saccharomyces cerevisiae conferred by msh1 alleles altered in the sequence encoding the ATP-binding domain.Semantic proximity Read ↗

Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway.Semantic proximity Read ↗

Negative epistasis between natural variants of the Saccharomyces cerevisiae MLH1 and PMS1 genes results in a defect in mismatch repair.Semantic proximity Read ↗

MSH5, a novel MutS homolog, facilitates meiotic reciprocal recombination between homologs in Saccharomyces cerevisiae but not mismatch repair.Semantic proximity Read ↗

Analysis of conditional mutations in the Saccharomyces cerevisiae MLH1 gene in mismatch repair and in meiotic crossing over.Semantic proximity Read ↗

Incompatibilities involving yeast mismatch repair genes: a role for genetic modifiers and implications for disease penetrance and variation in genomic mutation rates.Semantic proximity Read ↗

Systematic mutagenesis of the Saccharomyces cerevisiae MLH1 gene reveals distinct roles for Mlh1p in meiotic crossing over and in vegetative and meiotic mismatch repair.Semantic proximity Read ↗

Interactions of Exo1p with components of MutLalpha in Saccharomyces cerevisiae.Semantic proximity Read ↗

Mlh1 is unique among mismatch repair proteins in its ability to promote crossing-over during meiosis.Semantic proximity Read ↗

Functional specificity of MutL homologs in yeast: evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction.Semantic proximity Read ↗

DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.