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Article

Mitochondrial dysfunction due to oxidative mitochondrial DNA damage is reduced through cooperative actions of diverse proteins.

Molecular and cellular biology - 1 Jun 2002

O'Rourke Thomas W, Doudican Nicole A, Mackereth Melinda D, Doetsch Paul W, Shadel Gerald S

Abstract excerpt

The mitochondrial genome is a significant target of exogenous and endogenous genotoxic agents; however, the determinants that govern this susceptibility and the pathways available to resist mitochondrial DNA (mtDNA) damage are not well characterized. Here we report that oxidative mtDNA damage is elevated in strains lacking Ntg1p, providing the first direct functional evidence that this mitochondrion-localized,...

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Identifiers

PMID: 12024022
DOI: 10.1128/MCB.22.12.4086-4093.2002
PMCID: PMC133882

Genes

PIF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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