Article
A dominant mitochondrial mutator phenotype of Saccharomyces cerevisiae conferred by msh1 alleles altered in the sequence encoding the ATP-binding domain.
Molecular genetics and genomics : MGG - 1 Feb 2002
Koprowski P, Fikus M U, Mieczkowski P, Ciesla Z
Abstract excerpt
In order to improve our understanding of the role of the yeast MSH1 gene in error avoidance in mitochondrial DNA, two msh1 alleles were constructed, which encode proteins with amino acid substitutions in an ATP-binding domain that is highly conserved among MutS homologs. Here, we report that moderate overexpression of the msh1-R813W or msh1-G776D allele, in strains which also carry the wild-type MSH1 allele,...
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