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Article

Threonine 576 residue of amyloid-β precursor protein regulates its trafficking and processing.

Biochemical and biophysical research communications - 27 Nov 2015

Chun Yoon Sun, Kwon Oh-Hoon, Oh Hyun Geun, Kim Tae-Wan, McIntire Laura Beth, Park Myoung Kyu, Chung Sungkwon

Abstract excerpt

Deposition of amyloid-β (Aβ) in the brain is the main culprit of Alzheimer's disease (AD). Aβ is derived from sequential proteolytic cleavage of amyloid-β precursor protein (APP). Newly synthesized APP is transported from endoplasmic reticulum to the plasma membrane via trans-Golgi network (TGN) after post-translational modification including N- and O-glycosylation. APP is internalized through clathrin-dependent...

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Source

Identifiers

PMID: 26471307
DOI: 10.1016/j.bbrc.2015.10.037

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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