Article
A large multicentre analysis of CTGF -945 promoter polymorphism does not confirm association with systemic sclerosis susceptibility or phenotype.
Annals of the rheumatic diseases - 1 Oct 2009
Rueda B, Simeon C, Hesselstrand R, Herrick A, Worthington J, Ortego-Centeno N, Riemekasten G, Fonollosa V, Vonk M C, van den Hoogen F H J, Sanchez-Román J, Aguirre-Zamorano M A, García-Portales R, Pros A, Camps M T, Gonzalez-Gay M A, Gonzalez-Escribano M F, Coenen M J, Lambert N, Nelson J L, Radstake T R D J, Martin J
Abstract excerpt
OBJECTIVE: To conduct a replication study to investigate whether the -945 CTGF genetic variant is associated with systemic sclerosis (SSc) susceptibility or specific SSc phenotype. METHODS: The study population comprised 1180 patients with SSc and 1784 healthy controls from seven independent case-control sets of European ancestry (Spanish, French, Dutch, German, British, Swedish and North American). The -945 CTGF...
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