KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor.

doi:10.1186/ar4124

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Article

KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor.

Arthritis research & therapy - 27 Dec 2012

Bossini-Castillo Lara, Simeon Carmen P, Beretta Lorenzo, Broen Jasper, Vonk Madelon C, Callejas José Luis, Carreira Patricia, Rodríguez-Rodríguez Luis, García-Portales Rosa, González-Gay Miguel A, Castellví Ivan, Camps María Teresa, Tolosa Carlos, Vicente-Rabaneda Esther, Egurbide María Victoria, Schuerwegh Annemie J, Hesselstrand Roger, Lunardi Claudio, van Laar Jacob M, Shiels Paul, Herrick Ariane, Worthington Jane, Denton Christopher, Radstake Timothy R D J, Fonseca Carmen, Martin Javier

Abstract excerpt

INTRODUCTION: Potassium voltage-gated channel shaker-related subfamily member 5 (KCNA5) is implicated in vascular tone regulation, and its inhibition during hypoxia produces pulmonary vasoconstriction. Recently, a protective association of the KCNA5 locus with systemic sclerosis (SSc) patients with pulmonary arterial hypertension (PAH) was reported. Hence, the aim of this study was to replicate these findings in...

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Identifiers

PMID: 23270786
DOI: 10.1186/ar4124
PMCID: PMC3674598

Genes

PAH
KCNA5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor.PMID 23270786Read ↗

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