Article
The STAT4 gene influences the genetic predisposition to systemic sclerosis phenotype.
Human molecular genetics - 1 Jun 2009
Rueda B, Broen J, Simeon C, Hesselstrand R, Diaz B, Suárez H, Ortego-Centeno N, Riemekasten G, Fonollosa V, Vonk M C, van den Hoogen F H J, Sanchez-Román J, Aguirre-Zamorano M A, García-Portales R, Pros A, Camps M T, Gonzalez-Gay M A, Coenen M J H, Airo P, Beretta L, Scorza R, van Laar J, Gonzalez-Escribano M F, Nelson J L, Radstake T R D J, Martin J
Abstract excerpt
The aim of this study was to investigate the possible role of STAT4 gene in the genetic predisposition to systemic sclerosis (SSc) susceptibility or clinical phenotype. A total of 1317 SSc patients [896 with limited cutaneous SSc (lcSSc) and 421 with diffuse cutaneous SSc (dcSSc)] and 3113 healthy controls, from an initial case-control set of Spanish Caucasian ancestry and five independent cohorts of European...
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