Article
Single-nucleotide polymorphisms in CCL2 gene are not associated with susceptibility to systemic sclerosis.
The Journal of rheumatology - 1 May 2008
Carulli Maria Teresa, Spagnolo Paolo, Fonseca Carmen, Welsh Kenneth I, duBois Roland M, Black Carol M, Denton Christopher P
Abstract excerpt
OBJECTIVE: To validate the reported association between CC chemokine ligand 2 (CCL2) -2518 G single nucleotide polymorphism and systemic sclerosis (SSc) in a much larger cohort of patients. We also performed subgroup analysis to test the hypothesis that CCL2 variants predispose to specific disease phenotypes. METHODS: Ninety-four Caucasian patients with SSc and 102 matched controls were genotyped by...
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