Article
Non-host-reactive donor CD8+ T cells of Tc2 phenotype potently inhibit marrow graft rejection.
Blood - 1 Jun 1998
Fowler D H, Whitfield B, Livingston M, Chrobak P, Gress R E
Abstract excerpt
Donor CD8+ T cells capable of host reactivity inhibit marrow graft rejection, but also generate graft-versus-host disease (GVHD). To evaluate whether the Tc1- and Tc2-type subsets of CD8 cells might inhibit rejection without host reactivity, we established an F1 into-parent murine bone marrow tra...
Topics
- Animals
- Bone Marrow Transplantation
- CD8-Positive T-Lymphocytes
- Cells, Cultured
- Clonal Deletion
- Graft Rejection
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Phenotype
- T-Lymphocyte Subsets
- T-Lymphocytes, Cytotoxic