Article
IL-2 and IL-7 differentially induce CD4-CD8- alpha beta TCR+NK1.1+ large granular lymphocytes and IL-4-producing cells from CD4-CD8- alpha beta TCR+NK1.1- cells: implications for the regulation of Th1- and Th2-type responses.
International immunology - 1 Aug 1997
Nishizawa K, Koyasu S
Abstract excerpt
Effector functions of CD4-CD8- double negative (DN) alpha beta TCR+ cells were examined. Among mouse DN alpha beta TCR+ thymocytes, NK1.1+ cells expressing a canonical V alpha 14/J alpha 281 TCR but not NK1.1- cells produce IL-4 upon TCR cross-linking and IFN-gamma upon cross-linking of NK1.1 as...
Topics
- Animals
- Antigens
- Antigens, Ly
- Antigens, Surface
- Immunity, Cellular
- Immunoglobulin Variable Region
- Interleukin-2
- Interleukin-4
- Interleukin-7
- Lectins, C-Type
- Lymphocyte Activation
- Mice
- Mice, Inbred C57BL
- NK Cell Lectin-Like Receptor Subfamily B