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Article

Gene variants and mRNA expression analysis of SOCS3 and its association with serum IL-4 levels in atopic diseases.

Immunobiology - 1 May 2023

Hussain Showkat, Rasool Roohi, Shafi Tabasum, Gull Ayaz, Jan Rafi, Bhat Imtiyaz A, Haq Malik Gowharul, Shah Zafar Amin

Abstract excerpt

BACKGROUND: The suppressors of cytokine signaling (SOCS) are a class of negative regulators for several aspects of cytokine signaling that have been attributed to the pathophysiology of inflammatory disorders. Given the role of the SOCS3 gene in regulating Th2 cell proliferation, our study aimed to analyze two SOCS3 SNPs viz. rs8074003 and rs7222391, and their potential influence on IL-4 levels and SOCS3 mRNA...

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Identifiers

PMID: 37075578
DOI: 10.1016/j.imbio.2023.152387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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