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Article

Thiopurine S-methyltransferase (TPMT) activity is better determined by biochemical assay versus genotyping in the Jewish population.

Digestive diseases and sciences - 1 Jun 2014

Kasirer Yair, Mevorach Rephael, Renbaum Paul, Algur Nurit, Soiferman Devora, Beeri Rachel, Rachman Yelana, Segel Reeval, Turner Dan

Abstract excerpt

BACKGROUND: Thiopurine S-methyltransferase (TPMT) is a key enzyme that deactivates thiopurines, into their inactive metabolite, 6-methylmercaptopurine. Intermediate and low TPMT activity may lead to leukopenia following thiopurine treatment. The aim of this study was to determine TPMT activity and TPMT alleles (genotype-phenotype correlation) in Jews, aiming to develop an evidence-based pharmacogenetic assay for...

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Source

Identifiers

PMID: 24390675
DOI: 10.1007/s10620-013-3008-z

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TPMT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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