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Article

WNT5A is regulated by PAX2 and may be involved in blastemal predominant Wilms tumorigenesis.

Neoplasia (New York, N.Y.) - 1 Dec 2008

Tamimi Yahya, Ekuere Usukuma, Laughton Nicholas, Grundy Paul

Abstract excerpt

The PAX2 gene encodes a transcription factor expressed during development. In humans, PAX2 mutations cause the renal-coloboma syndrome, whereas homozygous mutations are lethal, causing severe organ malformation, notably in the brain and kidney. Wilms tumor (WT) of the kidney results from a failure in the mesenchymal-epithelial transition, a crucial step partly controlled by PAX2. Downstream target genes regulated...

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Source

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Identifiers

PMID: 19048125
DOI: 10.1593/neo.08442
PMCID: PMC2586697

Genes

PAX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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