Article
PAX3 is expressed in the stromal compartment of the developing kidney and in Wilms tumors with myogenic phenotype.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society - 1 Jan 2000
Hueber Pierre-Alain, Fukuzawa Ryuji, Elkares Reyhan, Chu Leelee, Blumentkrantz Miriam, He Shu-Jie, Anaka Matthew R, Reeve Anthony E, Eccles Michael, Jabado Nada, Iglesias Diana M, Goodyer Paul R
Abstract excerpt
Wilms tumor (WT) is the most frequent renal neoplasm of childhood; a myogenic component is observed in 5% to 10% of tumors. We demonstrate for the first time that myogenic WTs are associated with expression of PAX3, a transcription factor known to specify myoblast cell fate during muscle development. In a panel of 20 WTs, PAX3 was identified in 13 of 13 tumor samples with myogenic histopathology but was absent in...
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