Article

Tumour suppressor WT1 and its interacting protein RNA helicase DDX5 regulate the microRNA let7/Igf1r axis in the kidney mesenchyme

2025-01-05

Abstract excerpt

Germline mutations in tumour suppressor, Wilms Tumour 1 ( WT1 ) as well as somatic and germline mutations in microRNA processing genes (MIRPG) have been identified in Wilms’ Tumours (WT), where upregulation of IGF2 through genetic and/or epigenetic mechanisms is commonly seen. Whether these different epigenetic and genetic causes converge on common targets is still unclear. WT1 is also involved in RNA binding and...

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Literature Corpus work: 578c47c7-9ed3-5f0d-908b-aa3eb5ecd8ba
DOI: 10.1101/2025.01.05.631347

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