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Article

Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2008

Horikawa Yohei, Wood Christopher G, Yang Hushan, Zhao Hua, Ye Yuanqing, Gu Jian, Lin Jie, Habuchi Tomonori, Wu Xifeng

Abstract excerpt

PURPOSE: MicroRNAs (miRNA) are a class of small noncoding RNA molecules that have been implicated in a wide variety of basic cellular functions through posttranscriptional regulations on their target genes. Compelling evidence has shown that miRNAs are involved in cancer initiation and progression. We hypothesized that genetic variations of the miRNA machinery genes could be associated with the risk of renal cell...

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Topics

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Share to Carcinoma, Renal Cell
Share to RAN gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Kidney Neoplasms

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Share to Polymorphism, Single Nucleotide

Source

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Identifiers

PMID: 19047128
DOI: 10.1158/1078-0432.CCR-08-1199
PMCID: PMC2650498

Genes

GEMIN4
AGO1
AGO2
DGCR8
DICER1
DROSHA
RAN
TARBP2
XPO5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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