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Article

Total-genome analysis of BRCA1/2-related invasive carcinomas of the breast identifies tumor stroma as potential landscaper for neoplastic initiation.

American journal of human genetics - 1 Jun 2006

Weber Frank, Shen Lei, Fukino Koichi, Patocs Attila, Mutter George L, Caldes Trinidad, Eng Charis

Abstract excerpt

We have shown that the tumor microenvironment of sporadic breast cancer is diverse in genetic alterations and contributes to the cancer phenotype. The dynamic morphology of the mammary gland might be of special interest in hereditary breast/ovarian cancer syndrome (HBOC). We hypothesized that hot...

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Source

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Identifiers

PMID: 16685647
DOI: 10.1086/504090
PMCID: PMC1474086

Genes

BRCA1
POLD1
SDHB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16685647-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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