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Article

The Differential Profiling of Ubiquitin-Proteasome and Autophagy Systems in Different Tissues before the Onset of Huntington's Disease Models.

Brain pathology (Zurich, Switzerland) - 1 Jul 2015

Her Lu-Shiun, Lin Jian-Yu, Fu Mu-Hui, Chang Yu-Fan, Li Chia-Ling, Tang Ting-Yu, Jhang Yu-Ling, Chang Chih-Yi, Shih Meng-Chi, Cheng Pei-Hsun, Yang Shang-Hsun

Abstract excerpt

Huntington's disease (HD) is a genetic and neurodegenerative disease, leading to motor and cognitive dysfunction in HD patients. At cellular level, this disease is caused by the accumulation of mutant huntingtin (HTT) in different cells, and finally results in the dysfunction of different cells. To clean these mutant proteins, ubiquitin-proteasome system (UPS) and autophagy system are two critical pathways in the...

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Identifiers

PMID: 25178567
DOI: 10.1111/bpa.12191
PMCID: PMC8029242

Genes

HTT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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