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Behavioural phenotyping reveals anxiety-like features of SV2A deficient mice.

Behavioural brain research - 17 Mar 2009

Lamberty Yves, Detrait Eric, Leclercq Karine, Michel Anne, De Ryck Marc

Abstract excerpt

Synaptic vesicle protein 2A (SV2A) is involved in neurotransmitter release and has been identified as the binding site for levetiracetam (Keppra), a novel antiepileptic drug. Homozygous SV2A (-/-) mice are not viable beyond a few weeks. In contrast, heterozygous SV2A (+/-) mice have a normal lifespan. We performed a behavioural phenotyping on SV2A (+/-) mice in a battery of tests: gross behavioural observation,...

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Identifiers

PMID: 19041904
DOI: 10.1016/j.bbr.2008.11.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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