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Article

Proepileptic phenotype of SV2A-deficient mice is associated with reduced anticonvulsant efficacy of levetiracetam.

Epilepsia - 1 Jul 2009

Kaminski Rafal M, Gillard Michel, Leclercq Karine, Hanon Etienne, Lorent Geneviève, Dassesse Donald, Matagne Alain, Klitgaard Henrik

Abstract excerpt

PURPOSE: Synaptic vesicle protein 2A (SV2A) constitutes a distinct binding site for an antiepileptic drug levetiracetam (Keppra). In the present study we characterized SV2A (+/-) heterozygous mice in several seizure models and tested if the anticonvulsant efficacy of levetiracetam is reduced in t...

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Identifiers

PMID: 19486357
DOI: 10.1111/j.1528-1167.2009.02089.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19486357-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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