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Article

Development and Validation of a New Mouse Model to Investigate the Role of SV2A in Epilepsy.

PloS one - 1 Jan 2016

Menten-Dedoyart Catherine, Serrano Navacerrada Maria Elisa, Bartholome Odile, Sánchez Gil Judit, Neirinckx Virginie, Wislet Sabine, Becker Guillaume, Plenevaux Alain, Van den Ackerveken Priscilla, Rogister Bernard

Abstract excerpt

SV2A is a glycoprotein present in the membranes of most synaptic vesicles. Although it has been highly conserved throughout evolution, its physiological role remains largely unknown. Nevertheless, Levetiracetam, a very effective anti-epileptic drug, has been recently demonstrated to bind to SV2A. At present, our understanding of the normal function of SV2A and its possible involvement in diseases like epilepsy is...

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Identifiers

PMID: 27861538
DOI: 10.1371/journal.pone.0166525
PMCID: PMC5115750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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