Article

Pair Matcher ( <i>PaM</i> ): fast model-based optimisation of treatment\case-control matches using demographic and genetic data

2017-06-02

Abstract excerpt

In clinical trials, individuals are matched for demographic criteria, paired, and then randomly assigned to treatment and control groups to determine a drug’s efficacy. The successful completion of pilot trials is a prerequisite to larger and more expensive Phase III trials. One of the chief causes for the irreproducibility of results across pilot to Phase III trials is population stratification bias caused by the...

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Literature Corpus work: 8da13c16-15e0-5c2f-bfb8-dd74e4f5fbae
DOI: 10.1101/145177

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