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Article

Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.

European journal of immunology - 1 Dec 2008

Levin Ditza, DiPaolo Richard J, Brinster Carine, Revilleza Maria Jamela R, Boyd Lisa F, Teyton Luc, Natarajan Kannan, Mage Michael G, Shevach Ethan M, Margulies David H

Abstract excerpt

We examined TCR:MHC/peptide interactions and in vivo epitope availability to explore the Th1- or Th2-like phenotype of autoimmune disease in two TCR Tg mouse models of autoimmune gastritis (AIG). The TCR of strains A23 and A51 recognize distinct IA(d)-restricted peptides from the gastric parietal cell H/K-ATPase. Both peptides form extremely stable MHC/peptide (MHC/p) complexes. All A23 animals develop a Th1-like...

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Identifiers

PMID: 19039784
DOI: 10.1002/eji.200838584
PMCID: PMC2712832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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