Article
Availability of autoantigenic epitopes controls phenotype, severity, and penetrance in TCR Tg autoimmune gastritis.
European journal of immunology - 1 Dec 2008
Levin Ditza, DiPaolo Richard J, Brinster Carine, Revilleza Maria Jamela R, Boyd Lisa F, Teyton Luc, Natarajan Kannan, Mage Michael G, Shevach Ethan M, Margulies David H
Abstract excerpt
We examined TCR:MHC/peptide interactions and in vivo epitope availability to explore the Th1- or Th2-like phenotype of autoimmune disease in two TCR Tg mouse models of autoimmune gastritis (AIG). The TCR of strains A23 and A51 recognize distinct IA(d)-restricted peptides from the gastric parietal...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
