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Article

Autoantigen-specific TGFbeta-induced Foxp3+ regulatory T cells prevent autoimmunity by inhibiting dendritic cells from activating autoreactive T cells.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2007

DiPaolo Richard J, Brinster Carine, Davidson Todd S, Andersson John, Glass Deborah, Shevach Ethan M

Abstract excerpt

Several strategies are being designed to test the therapeutic potential of Ag-specific regulatory T cells to prevent or treat autoimmune diseases. In this study, we demonstrate that naive CD4+ Foxp3- T cells specific for a naturally expressed autoantigen (H+/K+ ATPase) can be converted to Foxp3+...

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Identifiers

PMID: 17878367
DOI: 10.4049/jimmunol.179.7.4685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17878367-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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