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Molecular Mimicry between <i>Helicobacter pylori</i> Antigens and H+,K+–Adenosine Triphosphatase in Human Gastric Autoimmunity

20 Oct 2003

Abstract excerpt

Autoimmune gastritis and Helicobacter pylori-associated gastric atrophy develop through similar mechanisms involving the proton pump H+,K+-adenosine triphosphatase as autoantigen. Here, we report that H. pylori-infected patients with gastric autoimmunity harbor in vivo-activated gastric CD4+ T cells that recognize both H+, K+-adenosine triphosphatase and H. pylori antigens. We characterized the submolecular...

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PMID: 14568977
DOI: 10.1084/jem.20030530

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