Extrathymic mechanisms of T cell tolerance: lessons from autoimmune gastritis.

Abstract excerpt

While the thymus plays a key role in the prevention of many autoimmune phenomena it is clear that robust mechanisms external to the thymus are also vital in controlling self-reactive T cells. Here we review the current concepts in the field of extrathymic tolerance and use recent studies of autoimmune gastritis to illustrate how T cells directed to a prominent, clinically relevant autoantigen, namely the gastric...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autoimmunity
• Share to Gastritis
• Share to Genetic Predisposition to Disease