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Article

An active foamy virus integrase is required for virus replication.

The Journal of general virology - 1 Jun 1999

Enssle J, Moebes A, Heinkelein M, Panhuysen M, Mauer B, Schweizer M, Neumann-Haefelin D, Rethwilm A

Abstract excerpt

Foamy viruses (FVs) make use of a replication strategy which is unique among retroviruses and shows analogies to hepadnaviruses. The presence of an integrase (IN) and obligate provirus integration distinguish retroviruses from hepadnaviruses. To clarify whether a functional IN is required for FV replication, a mutant in the highly conserved DD35E motif of the active centre was analysed. This mutant was found to...

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Source

Identifiers

PMID: 10374962
DOI: 10.1099/0022-1317-80-6-1445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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