Article
Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China.
Cancer letters - 8 Mar 2009
Zhang Yongjing, Liu Bing, Jin Mingjuan, Ni Qin, Liang Xia, Ma Xinyuan, Yao Kaiyan, Li Qilong, Chen Kun
Abstract excerpt
The TGF-beta signaling pathway plays a very important role in the control of cell proliferation and differentiation that is involved in colorectal carcinogenesis. The associations between polymorphisms of TGF-beta1 and its receptors genes and the colorectal cancer risk were assessed in a population-based case-control study (206 cases and 838 controls). We could not observe any variant in the G-800A, codon25 and...
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