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Article

Genetic polymorphism in the transforming growth factor beta1 gene (-509 C/T and -800 G/A) and colorectal cancer.

Cancer genetics and cytogenetics - 1 Apr 2009

Amirghofran Zahra, Jalali Seyed Amir, Ghaderi Abbas, Hosseini Seyed Vahid

Abstract excerpt

TGF-beta1 is a multifunctional cytokine that acts as both a tumor suppressor and a stimulator of tumor progression. Susceptibility to colorectal carcinoma may be affected by genetic factors. In this study, the association between -800 G/A and -509 C/T polymorphisms of the transforming growth factor beta1 gene, TGFB1, and susceptibility to colorectal cancer in Iranian patients was investigated. This study was...

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Source

Identifiers

PMID: 19264229
DOI: 10.1016/j.cancergencyto.2008.11.010

Genes

TGFB1

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Related research

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Genetic polymorphism in the transforming growth factor beta1 gene (-509 C/T and -800 G/A) and colorectal cancer.PMID 19264229Read ↗

TGFB1 509 C/T polymorphism and colorectal cancer risk: a meta-analysis.Semantic proximity Read ↗

Meta-analyses of the associations between four common TGF-β1 genetic polymorphisms and risk of colorectal tumor.Semantic proximity Read ↗

Transforming growth factor beta-1 C-509T polymorphism and cancer risk: a meta-analysis of 55 case-control studies.Semantic proximity Read ↗

An updated meta-analysis on the association of TGF-β1 gene promoter -509C/T polymorphism with colorectal cancer risk.Semantic proximity Read ↗

-509C>T polymorphism in the TGF-β1 gene promoter is not associated with susceptibility to and progression of colorectal cancer in Chinese.Semantic proximity Read ↗

Transforming growth factor-β1 gene promoter -509C/T polymorphism in association with expression affects colorectal cancer development and depends on gender.Semantic proximity Read ↗

Transforming growth factor-[beta]1 -509T reduces risk of colorectal cancer, but not adenoma in Koreans.Semantic proximity Read ↗

Role of transforming growth factor-β1 -509 C/T promoter polymorphism in gastric cancer in south Indian population.Semantic proximity Read ↗

Genetic polymorphisms of transforming growth factor-beta1 and its receptors and colorectal cancer susceptibility: a population-based case-control study in China.Semantic proximity Read ↗

Promoter polymorphism of transforming growth factor-beta1 gene and ulcerative colitis.Semantic proximity Read ↗

TGF-β1 polymorphism 509 C>T is associated with an increased risk for hepatocellular carcinoma in HCV-infected patients.Semantic proximity Read ↗

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