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Article

Silencing of IQGAP1 by shRNA inhibits the invasion of ovarian carcinoma HO-8910PM cells in vitro.

Journal of experimental & clinical cancer research : CR - 27 Nov 2008

Dong Pei-Xin, Jia Nan, Xu Zhu-Jie, Liu Ying-Tao, Li Da-Jin, Feng You-Ji

Abstract excerpt

BACKGROUND: IQGAP1 is a scaffolding protein and overexpressed in many human tumors, including ovarian cancer. However, the contribution of IQGAP1 to invasive properties of ovarian cancer cells remains unknown. Here, we investigated the effect of IQGAP1-specific short hairpin RNA (shRNA) expressing plasmids on metastatic potential of ovarian cancer HO-8910PM cells. METHODS: We used RT-PCR and Western blot analysis...

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Source

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Identifiers

PMID: 19036171
DOI: 10.1186/1756-9966-27-77
PMCID: PMC2626583

Genes

IQGAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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