Article
Identification and characterization of polyadenylation signal (PAS) variants in human genomic sequences based on modified EST clustering.
In silico biology - 1 Jan 2008
Kamasawa Masami, Horiuchi Jun-ichi
Abstract excerpt
A large-scale analysis of human polyadenylation signals was carried out in silico. The most canonical AAUAAA hexamer and its 11 single-nucleotide variants that are most frequent in human genes were used to search for polyadenylation signals in the terminal sequences. Out of 18,277 poly(A) sites that were identified from 26,414 human genes, 82.5% of the sites were found to contain at least one of these 12 hexamers...
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