Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.

The Journal of biological chemistry - 23 Jan 2009

Zhang Lei, Zhao Hui, Qiu Yu, Loh Horace H, Law Ping-Yee

Abstract excerpt

Recent studies have revealed that in G protein-coupled receptor signalings switching between G protein- and beta-arrestin (betaArr)-dependent pathways occurs. In the case of opioid receptors, the signal is switched from the initial inhibition of adenylyl cyclase (AC) to an increase in AC activity (AC activation) during prolonged agonist treatment. The mechanism of such AC activation has been suggested to involve...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenylyl Cyclases
Share to Arrestins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to beta-Arrestins

Share to Enzyme Activation

Share to Morphine

Share to Receptors, Opioid, mu

Share to src-Family Kinases

Share to Tyrosine

Source

Open in PubMed Open full text

Identifiers

PMID: 19029294
DOI: 10.1074/jbc.M807971200
PMCID: PMC2629085

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Src phosphorylation of micro-receptor is responsible for the receptor switching from an inhibitory to a stimulatory signal.PMID 19029294Read ↗

Atypical signaling and functional desensitization response of MAS receptor to peptide ligands.Semantic proximity Read ↗

Activation and nuclear translocation of ERK1/2 by the formyl peptide receptor is regulated by G protein and is not dependent on beta-arrestin translocation or receptor endocytosis.Semantic proximity Read ↗

Receptor activity modifying proteins.Semantic proximity Read ↗

Multisite phosphorylation is required for sustained interaction with GRKs and arrestins during rapid μ-opioid receptor desensitization.Semantic proximity Read ↗

CGRP-receptor family reveals endogenous GPCR agonist bias and its significance in primary human cardiovascular cellsSemantic proximity Read ↗

Biased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanisms.Semantic proximity Read ↗

Receptor-effector coupling by G proteins: implications for normal and abnormal signal transduction.Semantic proximity Read ↗

Receptor-Arrestin Interactions: The GPCR Perspective.Semantic proximity Read ↗

β-Arrestins 1 and 2 are critical regulators of inflammationSemantic proximity Read ↗

Are we beta-ARKing up the wrong tree? Casein kinase 1 alpha provides an additional pathway for GPCR phosphorylation.Semantic proximity Read ↗

Glucocorticoids regulate arrestin gene expression and redirect the signaling profile of G protein-coupled receptorsSemantic proximity Read ↗

Progress in demystification of adhesion G protein-coupled receptorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.