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Article

Progress in demystification of adhesion G protein-coupled receptors

21 Mar 2013

Abstract excerpt

Adhesion G protein-coupled receptors (aGPCR) form the second largest class of GPCR. They are phylogenetically old and have been highly conserved during evolution. Mutations in representatives of this class are associated with severe diseases such as Usher Syndrome, a combined congenital deaf-blindness, or bifrontal parietal polymicrogyria. The main characteristics of aGPCR are their enormous size and the...

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PMID: 23518449
DOI: 10.1515/hsz-2013-0109

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