Article
Array CGH analysis of chronic lymphocytic leukemia reveals frequent cryptic monoallelic and biallelic deletions of chromosome 22q11 that include the PRAME gene.
Leukemia research - 1 Sept 2009
Gunn Shelly R, Bolla Aswani R, Barron Lynn L, Gorre Mercedes E, Mohammed Mansoor S, Bahler David W, Mellink Clemens H M, van Oers Marinus H J, Keating Michael J, Ferrajoli Alessandra, Coombes Kevin R, Abruzzo Lynne V, Robetorye Ryan S
Abstract excerpt
We used BAC array-based CGH to detect genomic imbalances in 187 CLL cases. Submicroscopic deletions of chromosome 22q11 were observed in 28 cases (15%), and the frequency of these deletions was second only to loss of the 13q14 region, the most common genomic aberration in CLL. Oligonucleotide-based array CGH analysis showed that the 22q11 deletions ranged in size from 0.34 Mb up to approximately 1 Mb. The...
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