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Article

Clathrin heavy and light chain isoforms originated by independent mechanisms of gene duplication during chordate evolution.

Proceedings of the National Academy of Sciences of the United States of America - 17 May 2005

Wakeham Diane E, Abi-Rached Laurent, Towler Mhairi C, Wilbur Jeremy D, Parham Peter, Brodsky Frances M

Abstract excerpt

In humans, there are two isoforms each of clathrin heavy chain (CHC17 and CHC22) and light chain (LCa and LCb) subunits, all encoded by separate genes. CHC17 forms the ubiquitous clathrin-coated vesicles that mediate membrane traffic. CHC22 is implicated in specialized membrane organization in skeletal muscle. CHC17 is bound and regulated by LCa and LCb, whereas CHC22 does not functionally interact with either...

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Source

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Identifiers

PMID: 15883369
DOI: 10.1073/pnas.0502058102
PMCID: PMC1091751

Genes

CLTA
CLTB
CLTC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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