Article
Compromise of clathrin function and membrane association by clathrin light chain deletion.
Traffic (Copenhagen, Denmark) - 1 Dec 2003
Wang Jingshan, Virta Valerie C, Riddelle-Spencer Kathryn, O'Halloran Theresa J
Abstract excerpt
While clathrin heavy chains from different species are highly conserved in amino acid sequence, clathrin light chains are much more divergent. Thus clathrin light chain may have different functions in different organisms. To investigate clathrin light chain function, we cloned the clathrin light chain, clcA, from Dictyostelium and examined clathrin function in clcA-mutants. Phenotypic deficiencies in development,...
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