Article
Genealogy-based trait association with LOCATER boosts power at loci with allelic heterogeneity.
Genome research - 6 May 2026
Wang Xinxin, Christ Ryan, Young Erica, Kang Chul Joo, Das Indraniel, Belter Edward A, Laakso Markku, Aslett Louis J M, Steinsaltz David, Stitziel Nathan O, Hall Ira M
Abstract excerpt
A key methodological challenge for genome-wide association studies is how to leverage haplotype diversity and allelic heterogeneity to improve trait association power, especially in noncoding regions where it is difficult to predict variant impacts and define functional units for variant aggregation. Genealogy-based association methods have the potential to bridge this gap by testing combinations of common and...
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