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Article

Regulatory hotspots in the malaria parasite genome dictate transcriptional variation.

PLoS biology - 30 Sept 2008

Gonzales Joseph M, Patel Jigar J, Ponmee Napawan, Jiang Lei, Tan Asako, Maher Steven P, Wuchty Stefan, Rathod Pradipsinh K, Ferdig Michael T

Abstract excerpt

The determinants of transcriptional regulation in malaria parasites remain elusive. The presence of a well-characterized gene expression cascade shared by different Plasmodium falciparum strains could imply that transcriptional regulation and its natural variation do not contribute significantly to the evolution of parasite drug resistance. To clarify the role of transcriptional variation as a source of...

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Identifiers

PMID: 18828674
DOI: 10.1371/journal.pbio.0060238
PMCID: PMC2553844

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