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Article

COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study.

American journal of hypertension - 1 Jan 2009

Stewart Scott H, Oroszi Gabor, Randall Patrick K, Anton Raymond F

Abstract excerpt

BACKGROUND: Heavy drinking can cause chronic hypertension, possibly due to effects on the autonomic nervous system. Catechol- O-methyltransferase (COMT) inactivates catecholamines, and a G to A substitution in codon 108 in the soluble COMT mRNA (or codon 158 in the membrane-bound form) substitutes methionine for valine and alters enzyme activity. METHODS: We evaluated the association of COMT genotype at this...

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Source

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Identifiers

PMID: 19023276
DOI: 10.1038/ajh.2008.321
PMCID: PMC2630169

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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COMT genotype influences the effect of alcohol on blood pressure: results from the COMBINE study.PMID 19023276Read ↗

Association between the functional polymorphism of catechol-O-methyltransferase gene and alcohol consumption among social drinkers.Semantic proximity Read ↗

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High systolic blood pressure is associated with Val/Val genotype in the catechol-o-methyltransferase gene. The Nord-Trøndelag Health Study (HUNT).Semantic proximity Read ↗

The Role of the Catechol-o-Methyltransferase (COMT) GeneVal158Met in Aggressive Behavior, a Review of Genetic StudiesSemantic proximity Read ↗

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Catechol O-methyltransferase val158-met polymorphism is associated with abdominal obesity and blood pressure in men.Semantic proximity Read ↗

Association study between high and low activity polymorphism of catechol-O-methyltransferase gene and alcoholismSemantic proximity Read ↗

Sex differences in the influence of COMT Val158Met on alcoholism and smoking in plains American Indians.Semantic proximity Read ↗

Association of the Catechol-O-Methyl Transferase Gene Val158Met Polymorphism With Blood Pressure and Prevalence of Hypertension: Interaction With Dietary Energy IntakeSemantic proximity Read ↗

Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence.Semantic proximity Read ↗

COMBINE genetics study: the pharmacogenetics of alcoholism treatment response: genes and mechanisms.Semantic proximity Read ↗

The enzymatic activities of brain catechol-O-methyltransferase (COMT) and methionine sulphoxide reductase are correlated in a COMT Val/Met allele-dependent fashion.Semantic proximity Read ↗

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